Active B Complex provides the most biologically active forms and clinically relevant doses of a unique B vitamin combination. Quatrefolic folate provides (6S)-5-Methyltetrahydrofolate acid (MTHF), the active form of folate at the cellular level, the form found in circulation, and the only form able to cross the blood brain barrier. This form of folate bypasses enzymatic conversion by methylene tetrahydrofolate reductase (MTHFR), an enzyme with common genetic polymorphisms known to impair activity. Quatrefolic acid administration has been associated with higher peak (6S)-5-MTHF levels than both folic acid and calcium 5-MTHF, with higher plasma folate levels even in those with high functioning MTHFR polymorphisms.1, 2
In addition to superior folate bioavailability, Active B Complex contains superior forms of each B vitamin. Benfotiamine is a lipid soluble form of vitamin B1 with higher bioavailability than thiamine, used in the treatment of diabetic neuropathy because it blocks several hyperglycemic pathways and prevents endothelial dysfunction.3, 4, 5 Riboflavin 5’-phospate and pyridoxal 5’-phosphate (PLP) are biologically active forms of B2 and B6 – PLP being the most important member of the B6 group, and is the active coenzyme for more than 100 enzymes, bypassing hepatic conversion to an active form.6
Provides the natural and most bioactive form of folate, Quatrefolic folate (6S)-5-MTHF, with no synthetic or racemic components
Quatrefolic folate supplementation has greater increase in plasma folate compared to folic acid and calcium 5-MTHFR
Contains most bioactive and bioavailable forms of each B vitamin, including methylcobalamin (B12), riboflavin 5’-phosphate (B2), and pyridoxal 5’-phosphate (B6)
Broad spectrum B complex, with inositol, biotin, and choline
Suitable for vegetarians and vegans
Take 1 capsule per day with food or as directed by a health care practitioner.
Serving Size: 1 Capsule
Amount Per Serving
Vitamin B1 … 25mg
Benfotiamine … 10mg
Vitamin B2 … 10mg
(Riboflavin 5’-Phosphate Sodium)
Niacin … 100mg
Pantothenic Acid … 100mg
Vitamin B6 … 25mg
Vitamin B12 … 500mcg
Quatrefolic® Folate … 400mcg
((6S)-5-Methyltetrahydrofolate Acid (MTHF), Glucosamine Salt)
Biotin … 250mcg
Choline … 50mg
Inositol … 25mg
Non-medicinal Ingredients: Microcrystalline cellulose, vegetarian capsule (carbohydrate gum [cellulose], purified water), vegetable grade magnesium stearate (lubricant).
Contains no artificial colours, preservatives, or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, soy, corn, egg, fish, shellfish, animal products, salt, tree nuts, or GMOs. Suitable for vegetarians/ vegans.
Sealed for your protection. Do not use if seal is broken. For freshness, store in a cool, dry place.
Although several classes of drugs, such as aminoglycosides, anticonvulsants, bile acid sequestrants, and proton pump inhibitors, antihyperglycemic medications (Metformin), acne therapy (isotretinoin) are known to either interfere with B12 absorption or function, there are no known negative interactions caused by B12 supplementation with any medications.8-11 Metformin has been shown to deplete B12 and folate, and supplementation with B12 only in diabetics may be preferable.12
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent disease.